Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-12-20
2011-10-25
Morris, Patricia L (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S273400
Reexamination Certificate
active
08044073
ABSTRACT:
Aminobenzimidazoles and benzimidazoles having inhibitory activity on RSV replication and having the formulathe prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; wherein G is a direct bond or C1-10alkanediyl optionally substituted with one or more hydroxy, C1-6alkyloxy, Ar1C1-6alkyloxy, C1-6alkylthio, Ar1C1-6alkylthio, HO(—CH2—CH2—O)n—, C1-6alkyloxy(—CH2—CH2—O)n— or Ar1C1-6alkyloxy(—CH2—CH2—O)n—; R1is Ar1or a monocyclic or bicyclic heterocycle; Q is hydrogen, amino or mono- or di(C1-4alkyl)amino; one of R2aand R3ais selected from halo, optionally mono- or polysubstituted C1-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4b), N(R4aR4b)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, or —C(═Z)Ar2; and the other one of R2aand R3ais hydrogen; in case R2ais different from hydrogen then R2bis hydrogen, C1-6alkyl or halogen and R3bis hydrogen; in case R3ais different from hydrogen then R3bis hydrogen, C1-6alkyl or halogen and R2bis hydrogen. Compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
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Andries Koenraad Jozef Lodewijk
Bonfanti Jean-François
Doublet Frédéric Marc Maurice
Fortin Jér{hacek over (o)}me Michel Claude
Gevers Tom Valerius Josepha
Appollina Mary A.
Morris Patricia L
Tibotec Pharmaceuticals
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