Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1997-11-26
2000-10-03
Celsa, Bennett
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
560 8, 562493, 564305, 435DIG34, 435DIG40, C07C 6976, C07C 6304, C07C21100
Patent
active
061271918
ABSTRACT:
The present invention provides a library of compounds, each comprised of a common aminobenzenedicarboxylic acid core structure (scaffold) that serves as a template for synthesizing approximately 10.sup.1 -10.sup.6 compounds which are analogs of the scaffold. The library is employed to study ligand binding by biological receptors, such as enzymes, G-protein coupled receptors and membrane channels. For example, certain individual compounds within the library selectively bind and inhibit the action of trypsin-like serine proteases. The present invention also relates to combinatorial synthetic methods for making such libraries of compounds. Additionally, the present invention relates to novel scaffold-modified solid supports, particularly scaffold-modified polymer resins and methods for preparing said resins. Further, the present invention is directed to methods for screening a compound or plurality of compounds made according to the synthetic methods disclosed herein, which comprise using the compounds in suitable assays developed for detecting the compounds' utility as pharmaceutical agents.
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Fedde Cynthia L.
Graybill Todd L.
Salvino Joseph M.
Subasinghe Nalin
Wu Zhengdong
3-Dimensional Pharmaceuticals Inc.
Celsa Bennett
Ricigliano Joseph W.
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