Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-09-25
2000-03-14
Owens, Amelia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514365, 514457, 514465, 548204, 549288, 549320, 549321, A61K 3134, C07D30512
Patent
active
060373652
ABSTRACT:
This invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions of such compounds and a method of treatment to inhibit aggregation of platelets.
REFERENCES:
patent: 4517686 (1985-05-01), Ruoslahti
patent: 4578079 (1986-03-01), Ruoslahti
patent: 4589881 (1986-05-01), Pierschbacher
patent: 4614517 (1986-09-01), Ruoslahti
patent: 4661111 (1987-04-01), Ruoslahti
patent: 4997667 (1991-03-01), Nofre
patent: 5039805 (1991-08-01), Alig
patent: 5084466 (1992-01-01), Alig
patent: 5100875 (1992-03-01), Marguerie
patent: 5220050 (1993-06-01), Bovy
patent: 5270319 (1993-12-01), Belliotti
patent: 5344957 (1994-09-01), Bovy
patent: 5597825 (1997-01-01), Himmelsbach
M. Taddei et al., "Electrophilic Hydroxylation with Bis(trimethylsilyl) peroxxide", Synthesis, No. 8, pp. 633-635 (1986).
E.C. Horning et al., eds., Org. Synth., coll. vol. 3, John Wiley & Sons, New York, pp. 140-141 (1955).
J.R. Luly et al., "A Synthesis of Protected Aminoalkyl Epoxides from .alpha.-Amino Acids", J. Org. Chem., vol. 52, pp. 1487-1492 (1987).
S.G. Davies et al., "Asymmetric Synthesis of R-.beta.-Amino Butanoic Acid and S-.beta.-Tyrosine: Homochiral Lithium Amide Equivalents for Michael Additions to .alpha.,.beta.-Unsaturated Esters", Tetrahedron: Asymmetry, vol. 2, No. 3, pp. 183-186 (1991).
R.T. Boere et al., "Preparation of N, N, N'-tris(trimethylsilyl)amidines; a conventient route to unsubstituted amidines", J. Organomet. Chem., vol. 331, pp. 161-167 (1987).
W.E. Parham et al., "Aromatic Organolithium Reagents Bearing Eelctrophilic Groups", Acct. Chem. Res., vol. 15, pp. 300-305 (1982).
D.M. Haverstick et al., "Inhibition of Platelet Adhesion to Fibronectin, Fibrinogen, and von Willebrand Factor Substrates by a Synthetic Tetrapeptide Derived From the Cell-binding domain of Fibronectin", Blood, vol. 66, No. 4, pp. 946-952 (1985).
E. Ruoslahti et al., "New Perspectives in Cell Adhesion: RGD and Integrins", Science, vol. 238, pp. 491-497 (1987).
J.A. Zablocki et al., "Potent in Vitro and in Vivo Inhibitors of Platelet Aggregation Based Upon the Arg-Gly-Asp Sequence of Fibrinogen", J. Med. Chem., vol. 38, pp. 2378-2394 (1995).
C. F. Stanfield et al., "Preparation of Protected Amino Aldehydes", J. Org. Chem., vol. 46, pp. 4797-4789 (1981).
M. Kloczewiak et al., "Platelet Receptor Recognition Site on Human Fibrinogen", Biochem., vol. 23, No. 8, pp. 1767-1774 (1984).
E.F. Plow et al., "The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets", Proc. Nat'l Acad. Sci., vol. 82, No. 23, pp. 8057-8061 (1985).
Z.M. Ruggeri et al., "Inhibition of platelet function with synthetic peptides designed to be high-affinity antagonists of fibrinogen binding to platelets", Proc. Nat'l Acad. Sci., vol. 83, No. 15, pp. 5708-5712 (1986).
M. Ginsberg et al., "Inhibition of Fibronectin Binding to Platelets by Proteolytic Fragments and Synthetic Peptides Which Support Fibroblast Adhesion", J. Biol. Chem., vol. 260, No. 7, pp. 3931-3936 (1985).
Bovy Philippe Roger
Rico Joseph Gerace
Rogers Thomas Edward
G.D. Searle & Co.
Owens Amelia
LandOfFree
Aminobenzamidinosuccinyl lactone derivatives useful as inhibitor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aminobenzamidinosuccinyl lactone derivatives useful as inhibitor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminobenzamidinosuccinyl lactone derivatives useful as inhibitor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-169626