Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-08-07
2007-08-07
Balasubramanian, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S268100, C546S139000, C546S152000, C544S238000, C544S333000, C544S405000, C544S111000, C514S231500, C514S252010, C514S252100, C514S256000, C514S307000, C514S311000
Reexamination Certificate
active
10952471
ABSTRACT:
This invention relates to a novel compound represented by the formula (I):or a pharmaceutically acceptable salt thereof,whereinR1is —S(O)p-A, —S—(O)q-B or —O-D, wherein p and q, which are the same or different, each represent an integer from 0 to 2, A is a straight chain C1-C10 alkyl group which may be substituted by R10, and B and D each independently represent R12which may be substituted by R10;R2is a hydrogen atom, a halogen atom, or a straight chain or branched C1-C6 alkyl group which may be substituted by R10;X1and X2each independently represent N or CH, but cannot both be N;the formula (II):shows a monocyclic or bicyclic heteroaryl group which has a nitrogen atom adjacent to the carbon atom bonded to the amide group, and the heteroaryl group may be substituted by R10;R10is R11, or a hydrocarbon group which may be substituted by R11;R11is, for example, a hydrogen atom or amino; andR12is, for example, phenyl, thiazolyl, pyridyl or methylene dioxyphenyl.The compound according to this invention has a glucokinase activation effect, and for example, is useful in the treatment and prevention of diabetes mellitus, and in the prevention of its complications such as diabetic nephropathy, diabetic retinopathy, diabetic neuropathy and diabetic arteriosclerosis.
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Eiki Jun-ichi
Iino Tomoharu
Nagata Yasufumi
Nishimura Teruyuki
Balasubramanian Venkataraman
Banyu Pharmaceutical Co. Ltd.
Billups Richard C.
Fitch Catherine D.
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