Aminoalkylsulfides, aminoalkylsulfoxides, and aminoalkylsulfones

Details Aminoalkylsulfides, aminoalkylsulfoxides, and aminoalkylsulfones Aminoalkylsulfides, aminoalkylsulfoxides, and aminoalkylsulfones

1979-06-18

1981-07-28

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544129, 544141, 544159, 546121, 546208, 546232, 2603265S, 2603265SF, 26032684, 42424852, 424267, 424274, 424330, 564341, C07D41312, C07D29508, A61K 31535, A61K 31445

Patent

active

042811180

ABSTRACT:
Novel aminoalkylsulfides, aminoalkylsulfoxides and aminoalkylsulfones of the general formula ##STR1## wherein y and z independently represent the integer 0, 1 or 2; a represents the integer 0 or 2; n represents the integer 1, 2, 3 or 4; R.sub.1 independently represent lower alkyl or hydrogen or alternatively R.sub.1 and R.sub.2 taken together with the adjacent nitrogen atom represent a 5 or 6 membered heterocyclic ring which may optionally contain an oxygen atom whereby a morpholino, piperidino, or pyrrolidino grouping is formed; R.sub.3 represents halo such as chloro or bromo, lower alkylthio, arloweralkylthio, arylthio such as 4-methylphenylthio, 4-morpholinylloweralkylthio such as 4-morpholinylpropylthio, lower alkyl or arloweralkylamino such as 4-methoxybenzenemethanamino; R.sub.4 represents hydrogen or lower alkyl. The invention also includes the pharmaceutically-acceptable salts of the compounds described herein.

REFERENCES:
patent: 2659756 (1953-11-01), Hafliger et al.
patent: 4134996 (1979-01-01), Dunbar et al.
patent: 4141983 (1979-02-01), Dunbar et al.
patent: 4155907 (1979-05-01), Dunbar et al.
Allingham et al., Israel Journal of Chemistry, vol. 9, pp. 583-587 (1971).

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