Aminoalkylpyrrolidinylthiocarbapenem derivatives

Details Aminoalkylpyrrolidinylthiocarbapenem derivatives Aminoalkylpyrrolidinylthiocarbapenem derivatives

1994-09-27

1996-08-27

Rizzo, Nicholas

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540350, C07D48704, A61K 3140

Patent

active

055501214

ABSTRACT:
A compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a methyl group, R.sup.2 is a hydrogen atom or a negative charge, R.sup.3 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkoxy group, a lower alkanoyloxy group, an amino group, an N-lower alkylamino group, an N,N-di-lower alkylamino group, a lower alkanoylamino group, an aroylamino group, a (lower alkylsulfonyl)amino group, a sulfamoylamino group, a cyano group, a nitro group, a group of --COOR.sup.4 (wherein R.sup.4 is a hydrogen atom or a lower alkyl group) or a group of --CON(R.sup.5)R.sup.6 (wherein each of R.sup.5 and R.sup.6 which may be the same or different, is a hydrogen atom or a lower alkyl group, or R.sup.5 and R.sup.6 form together with the adjacent nitrogen atom a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidyl group, a piperazinyl group, a 4-lower alkyl piperazinyl group and a morpholino group), A is a linear or branched lower alkylene group, X is a group of --N(R.sup.7)R.sup.8 (wherein each of R.sup.7 and R.sup.8 which may be the same or different, is a hydrogen atom or a lower alkyl group) or a group of --N.sup.+ (R.sup.9)(R.sup.10)R.sup.11 (wherein each of R.sup.9, R.sup.10 and R.sup.11 which may be the same or different, is a lower alkyl group), provided that when A is a linear lower alkylene group, R.sup.3 is other than a hydrogen atom; or a pharmaceutically acceptable salt or ester thereof.

REFERENCES:
patent: 4740507 (1988-04-01), Sunagawa et al.
patent: 5093328 (1992-03-01), Sunagawa et al.
patent: 5449672 (1995-09-01), Nakagawa et al.

Affiliated with

Also associated with

Rating

Aminoalkylpyrrolidinylthiocarbapenem derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aminoalkylpyrrolidinylthiocarbapenem derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminoalkylpyrrolidinylthiocarbapenem derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1056282