Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-11-20
1997-07-15
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546329, 546334, C07D21302, A61K 3144
Patent
active
056483694
ABSTRACT:
Pharmaceutical compositions comprise as the active ingredient potent orally active, nonneurotoxic anticonvulsant compounds that are excitatory amino acid and NMDA/sigma receptor antagonists and that are selected from the group consisting of those of the formulae: ##STR1## wherein R.sup.1 is 4-pyridyl or 3-pyridyl, R.sup.2 is hydrogen or methyl and R.sup.3 is 3,4-dichloro, p- or m-chloro, p-bromo, p-fluoro, p-methyl, p-methoxy or hydrogen. The compositions are administered to mammals in an amount to provide a dosage amount ranging from about 15 mg/kg to 200 mg/kg.
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patent: 3654290 (1972-04-01), Berger
patent: 4358466 (1982-11-01), Haken et al.
Roger J. Porter, et al, "Antiepileptic Drug Development Program" The Cleveland Clinic Quarterly, vol. 51, No. 2, Summer 1984, pp. 293-305.
Dennis W. Choi, "Methods for Antagonizing Glutamate Neurotoxicity" Cerebrovasc Brain Metab Rev. vol. 2, No. 2, 1990, pp. 105-147.
Davis Zinna N.
Ivy C. Warren
University of Kentucky Research Foundation
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