Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-12-16
1996-07-16
Jones, W. Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 6, 536 231, 536 243, 536 2533, 536 256, 536 265, 536 266, C07H 2100, C07H 2102, C07H 2104, C12Q 168
Patent
active
055368212
ABSTRACT:
Disclosed are methods of producing a synthetic oligonucleotide of selected nucleotide sequence which is internally functionalized at at least one selected location with an aminoalkylphosphorothioamidate and labelled with a nonradioactive material. Also disclosed are oligonucleotides produced by this method.
REFERENCES:
patent: 4762779 (1988-08-01), Snitman
patent: 4959463 (1990-09-01), Froehler et al.
patent: 4965349 (1990-10-01), Woo et al.
patent: 5218103 (1993-06-01), Caruthers et al.
patent: 5317098 (1994-05-01), Shizuya et al.
Haralambidis et al. (1990) Nucleic Acids Res. 18:493-499.
Haralambidis et al. (1990) Nucleic Acids Res. 18:501-505.
Agrawal et al. (1989) Tetrahedron Letters 30(50): 7025-7028.
Fidanza et al. (1989) J. Am. Chem. Soc. 111:9117-9119.
Helene & Toulme, (1989) Oligonucleotides (Cohen, ed.) MacMillan Press, pp. 137-167.
Nelson et al. (1989) Nucleic Acids Res. 17:7187-7194.
Agrawal et al. (1988) Proc. Natl. Acad. Sci. (USA) 85:7079-7083.
Agrawal et al. (1988) J. Cell Biology 107:468.
Cardullo et al. (1988) Proc. Natl. Acad. Sci. (USA) 85:8790-8794.
Froehler et al. (1988) Nucleic Acids Res. 16:4831-4839.
Jager et al. (1988) Biochemistry 27:7237-7246.
Letsinger et al. (1988) J. Am. Chem. Soc. 110:4470-4471.
Matthews et al. (1988) Analytical Biochem. 169:1-25.
Agrawal et al. (1987) Tetrahedron Letters 28(31):3539-3542.
Caruthers et al. (1987) Methods in Enzymology 154:287-313.
Le Doan et al. (1987) Nucleic Acids Res. 15:8643-8659.
Agrawal et al. (1986) Nucleic Acids Res. 14:6227-6245.
Nevinski et al. (1983) Chemical Abstracts 99(5):35050 (Aug. 1, 1993).
Dobranravova et al. (1983) Chemical Abstracts 98(7):54383 (Feb. 14, 1983).
Zwierzak A. (Aug. 1975) Synthesis International Journal of Methods in Synthetic Organic Chemistry"Communications" pp. 507-509.
Uhlmann et al. Chemical Reviews 90(4): 544-584, 1990.
Agrawal Sudhir
Tang Jin-Yan
Jones W. Gary
Tran Paul B.
Worcester Foundation for Biomedical Research
LandOfFree
Aminoalkylphosphorothioamidate oligonucleotide deratives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aminoalkylphosphorothioamidate oligonucleotide deratives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminoalkylphosphorothioamidate oligonucleotide deratives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1785389