Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1994-07-21
1997-01-21
Springer, David B.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
530405, 530403, 548546, C08L 7704, A61K 3702, A61K 39385
Patent
active
055957412
ABSTRACT:
The invention concerns new aminoalkylmaleimides of the general formula I ##STR1## in which R.sub.1 and R.sub.2 are the same or different and represent hydrogen or a C.sub.1 -C.sub.4 alkyl group and A represents a straight-chain or branched, saturated or unsaturated alkylene group with 2 to 6 carbon atoms which is interrupted, if desired, by an oxygen or sulphur atom or a carbonyl group, as well as their corresponding acid addition salts.
The present invention also concerns amidoalkylmaleimide derivatives formed from compounds of the general formula I and immunological binding partners. In addition, the invention concerns immunological conjugates which can be produced by reaction of the amidoalkylmaleimide derivatives with peptides or proteins.
The subject matter of the present invention are also the corresponding processes of production of the compounds according to the present invention as well as the use of these conjugates in diagnostic methods of determination, in particular in immunoassays.
REFERENCES:
patent: 4276206 (1981-06-01), Katz
patent: 4902506 (1990-02-01), Anderson et al.
Batz Hans-Georg
Huber Emasmus
Klein Christian
Zink Bruno
Boehringer Mannheim GmbH
Springer David B.
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