Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-09-25
2007-09-25
Powers, Fiona T (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S274000, C514S275000, C544S008000, C544S316000, C544S331000
Reexamination Certificate
active
10999187
ABSTRACT:
The present invention concerns compounds of formula (I)a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z1-Z2- is a bivalent radical; R1, R2and R3are each independently selected from hydrogen, C1-6alkyl, hydroxy, halo and the like; or when R1and R2are on adjacent carbon atoms, R1and R2taken together may form a bivalent radical of formula; Alk1and Alk2are optionally substituted C1-6alkanediyl; R6is hydrogen or phenylmethyl; R5is a radical of formulawherein n is 1 or 2; p1is 0, and p2is 1 or 2; or p1is 1 or 2, and p2is 0; X is oxygen, sulfur or ═NR9; Y is oxygen or sulfur; R7is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl; R8is C1-6alkyl, C3-6cycloalkyl phenyl or phenylmethyl; R9is cyano, C1-6alkyl, C3-6cyclo-alkyl, C1-6alkyloxycarbonyl or aminocarbonyl; R10is hydrogen or C1-6alkyl; and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impaired fundic relaxation.
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T. Arakawa, U. Hironori, F. Takashi, K. Higuchi, K, Kobayashi, T. Kuroki, New Aspects of Gastric Adaptive Relaxation, Reflex after Food Intake for More Food: Involvement of Capsaicin-sensitive Sensory Nerves and Nitric Oxide, 1997, J. Smooth Muscle Res. 33:81-88.
De Bruyn Marcel Frans Leopold
Van Emelen Kristof
Janssen Pharmaceutica N.V.
Powers Fiona T
Woodcock & Washburn LLP
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