Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-04-01
2000-11-14
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
540476, 540597, 544106, 544336, 544361, 544250, 546 87, A61K 31437, A61P 912, C07D47104
Patent
active
061470856
ABSTRACT:
Disclosed are compounds of the formula: ##STR1## wherein Ar, R.sup.1, W and X are substituents as defined herein, which compounds are (1) antagonists at CRF.sub.1 receptors and are, therefore, useful in the diagnosis and treatment of stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety; and (2) are neuropeptide Y.sub.1 receptor antagonists, and are therefore useful in the treatment of a variety of clinical conditions which are characterized by the presence of an excess of neuropeptide Y.
REFERENCES:
patent: 5955613 (1999-09-01), Horvath et al.
C. E. Muller et al., Journal of Medicinal Chemistry, vol. 39, 1996, pp. 2482-2491.
K. Eger et al., Liebigs Annalen Der Chemie., 1993, pp. 465-470.
C. E. Muller et al., Journal of Medicinal Chemistry, vol. 33, 1990, pp. 2822-2828.
Darrow James W.
Horvath Raymond F.
Maynard George D.
Balasubramanian Venkataraman
Neurogen Corporation
Sarussi Steven J.
Shah Mukund J.
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