Aminoalkyl sterol compounds having an anti-tumoral and...

Details Aminoalkyl sterol compounds having an anti-tumoral and... Aminoalkyl sterol compounds having an anti-tumoral and...

2011-05-24

2011-05-24

Badio, Barbara P (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

C514S182000, C540S108000, C552S515000

Reexamination Certificate

active

07947668

ABSTRACT:
Sterol derivatives of formula (I) and a method for the production of the compounds, a medicament using one of the compounds and a pharmaceutical composition comprising the medicament.

REFERENCES:
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patent: 97/10836 (1997-03-01), None
El Kihel et al., “Synthesis and cytotoxicity of aminosterols: Activity studies on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6).” Anticancer Research, vol. 19, pp. 1229-1234, 1999.
Pinhas et al., “6-Amino derivatives of stigmastanol and cholestanol,”J. Med. Chem. (1971), 14(11), 1048-0 XP002220449, p. 1048-9.
Elkihel et al., “Synthesis of aminocholesterol derivatives with antibiotic properties”,Synthetic Communications, (1997), 27(11), XP008010386 pp. 1951-1962.
Elkihel, L. et al., “Synthesis and preliminary in vitro evaluation of antitumor nitrosoureido cholesterol derivatives”,Arzneimittel-Forschung, (1995), 45(2), XP-002220450, pp. 190-194.
Shafiullah et al., “Syntheses of steroidal substituted tetrazoles”,ACTA Chimica Hungarica, vol. 127, No. 3, 1990, XP008010474 pp. 391-394.
El Kihel, L. et al., Synthesis and cytotoxicity of aminosterols: Activity studies on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6),Anticancer Research, (1999), 19(2A), XP008010475, pp. 1229-1234.
Suh, N. et al., A novel synthetic oleanane triterpenoid, 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity,Cancer Research, United States Jan. 15, 1999, vol. 59, No. 2, XP-002220453, pp. 336-341.

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