Aminoalkyl secocanthine derivatives and their use

Details Aminoalkyl secocanthine derivatives and their use Aminoalkyl secocanthine derivatives and their use

1987-06-30

1989-06-06

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 94, A61K 31395, C07D47102

Patent

active

048372404

ABSTRACT:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R.sub.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halogen;
R.sub.2 and R.sub.3 are both hydrogen or together represent a bond;
R.sub.4 is hydrogen and R.sub.5 is hydrogen or R.sub.4 and R.sub.5 together represent an oxo group;
R.sub.6 is phenyl, phenyl C.sub.1-7 alkyl or phenyl C.sub.1 -7 alkanoyl, in which the phenyl moiety is substituted by NR.sub.8 R.sub.9 wherein R.sub.8 is C.sub.1-6 alkyl substituted by a group R.sub.10 selected from hydroxy, halo, CF.sub.3 or COR.sub.11 where R.sub.11 is hydroxy, C.sub.1-4 alkoxy or amino optionally substituted by one or two C.sub.1-4 alkyl groups, and R.sub.9 is hydrogen, C.sub.1-6 alkyl or R.sub.8 ; and
R.sub.7 is hydrogen or C.sub.1-4 alkyl.

REFERENCES:
patent: 4328343 (1982-05-01), Vollhardt et al.
patent: 4595688 (1986-01-01), Maryanoff
patent: 4624954 (1986-11-01), Jirkovsky et al.
Yoshio et al., J. Am. Chem. Soc., 1981, 103, 6990-2.
Yoshio et al., Chem. Abstracts, vol. 100, 175109c, (1984).
Yoshio et al., Chem. Abstracts, vol. 96, 20336c, (1982).
Yoshio et al., Chem. Abstracts, vol. 93, 168461v, (1980).
Verpoorte et al., Chem. Abstracts, vol. 100, 64933x, (1984).
Yoshio et al., Chem. Abstracts, vol. 92, 198606t, (1980).
Verpoorte et al., J. Med. Plant Res., 48, (1983), 283-289.

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