Aminoalkyl phenyl selenides for the treatment of hypertension an

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Sulfur – selenium or tellurium compound

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A61K 31095

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active

047229403

ABSTRACT:
The preparation of aminoalkyl phenyl selenides and pharmaceutically acceptable salts thereof is disclosed which are useful for the treatment of hypertension and related vascular diseases and the treatment of nervous system dysfunctions.

REFERENCES:
patent: 4415591 (1983-11-01), May et al.
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Judy et al., "Sympathetic Nerve Activity, Role in Regulation of Blood Pressure and Spontaneously Hypertensive Rat," Supp. II, Cir. Res., vol. 38, No. 6, Jun. 1976, 21-29.
Reich, "Organoselenium Oxidations", (1978), Oxidation in Organic Chemistry, Part C., Chapter 1, 1-130.
Lau, "Arylthio (or seleno, or sulfonyl) methyl-substituted phenolic compounds as photographic Couplers," 25-Noncondensed Aromatics, vol. 80, 351, (1974).
J. Heck et al., Chem. Abst. 96: 162,393q (1982).
S. Murahashi, J.A.C.S. 102(7): 2456-2458 (1980)-"Novel Transformation of Primary, Secondary and Tertiary Amines to Organo Selenides with Ruthenium Catalyst".
D. Seebach et al., Chem. Abstracts 87: 117652(b), (1977).
H. Reich et al., J. Org. Chem. 44(18): 3148-51 (1979)-Organoselenium Chemistry Dealkylation of Amines with Benzeneselenol.

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