Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Sulfur – selenium or tellurium compound
Patent
1987-10-13
1990-03-06
Wax, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Sulfur, selenium or tellurium compound
A61K 31095
Patent
active
049066684
ABSTRACT:
The preparation of aminoalkyl phenyl selenides and pharmaceutically acceptable salts thereof is disclosed which are useful for the treatment of hypertension and related vascular diseases and the treatment of nervous system dysfunctions.
REFERENCES:
patent: 4415591 (1983-11-01), May et al.
Bey et al., "Further Studies on the Inhibition of Monoamine Synthesis by Monofluoromethyldopa," Br. J. Pharmac., vol. 70, pp. 571-576, 1980.
Judy et al., "Sympathetic Nerve Activity role in Regulation of Blood Pressure and Spontaneously Hypertensive Rat," Supp. II, Cir. Res., vol. 38, No. 6, Jun. 1976, 21-29.
Reich "Organoselenium Oxidations," Oxidation in Organic Chemistry, Part C, Chapter 1, 1-130.
Lau, "Arylthio (or Seleno, or Sulfonyl) Methyl-Substituted Phenolic Compounds as Photographic Couplers," 25-Noncondensed Aromatics, vol. 80, 351, 1974.
Heck et al., Chem. Abstracts 96:162393q (1982).
Seebach et al., Chem. Abstracts 87:1176526b (1977).
Murahashi, "Novel Transformation of Primary, Secondary and Tertiary Amines to Orgaono Selenides with Ruthenium Catalyst," J.A.C.S. 102(7), pp. 2456-2458, 1980.
Reich et al., "Organoselenium Chemistry Dealkylation of Amines with Benzeneselenol," J. Org. Chem. 44(18), pp. 3148-3151, 1979.
Herman Heath H.
May Sheldon W.
Roberts Steven F.
Georgia Tech Research Corporation
Wax Robert
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