Aminoalkyl glucosaminide phosphate compounds and their use...

Details Aminoalkyl glucosaminide phosphate compounds and their use... Aminoalkyl glucosaminide phosphate compounds and their use...

2006-06-20

2006-06-20

Housel, James (Department: 1648)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C424S270100, C536S001110, C536S018400, C536S117000, C536S119000

Reexamination Certificate

active

07063967

ABSTRACT:
Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosaminide ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for using the compounds as adjuvants and immunoeffectors are also disclosed.

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