Aminoalkyl ethers of phenols as anticancer agents for the breast

Details Aminoalkyl ethers of phenols as anticancer agents for the breast Aminoalkyl ethers of phenols as anticancer agents for the breast

1987-07-06

1989-02-07

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

5142392, A61K 31135, A61K 31535

Patent

active

048032271

ABSTRACT:
The use of (a) N,N-dialkyl-2-[(4-phenylmethyl)phenoxy]ethanamine and N-morpholino-2-[(4-phenylmethyl)phenoxy]ethanamine compounds and their salts, as anticancer agents, is described. These compounds bind significantly to the anti-estrogen binding sites but only poorly to the estrogen receptor sites, and are cytotoxic to cancer cells. Compositions including mixtures of these ethanamine compounds (a) with (b) therapeutically active anticancer compounds such as tamoxifen, have been found particularly beneficial.

REFERENCES:
Cheney et al., J. of Am. Chem. Society, 71 (1949), pp. 60-64.

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