Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-12
2000-10-31
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514311, 514314, 546152, 546176, 546180, 546182, 546177, 546171, 546178, C07D21500, C07D21502, A61K 3147
Patent
active
061403415
ABSTRACT:
Aminoalkyl and acylaminoalkyl ethers which are distinguished by high affinity for the bradykinin B.sub.2 receptor and improved solubility in water are described. These aminoalkyl and acylaminoalkyl ethers can be represented by the formula (I) ##STR1## in which R.sup.1,R.sup.2,R.sup.3 are alkyl, aryl, alkylaryl, halogen, hydrogen, cycloalkyl, CHO, CO--O-alkyl, COOH; R.sup.4, R.sup.5 are hydrogen, halogen, alkoxy, nitro, cyano, S-alkyl; n is a number from 1 to 8; R.sup.6 is hydrogen, alkyl, alkylalkenyl, alkylaryl; R.sup.7 is hydrogen and a substituted or unsubstituted acyl radical. A process for preparing the compounds of the formula (I) is likewise described.
REFERENCES:
patent: 5216165 (1993-06-01), Mobilio et al.
patent: 5288725 (1994-02-01), Witherup et al.
D. Hoyer et al., ACE inhibitors as a template for the design of bradykinin B.sub.2 receptor antagonists, Chemical Abstracts, vol. 123(9): 111822x (1995).
Heitsch Holger
Nolken Gerhard
Scholkens Bernward
Wagner Adalbert
Wirth Klaus
Dees Jos,e G.
Hoechst Aktiengesellschaft
Qazi Sabiha N.
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