Aminoalkoxy or carboxyalkoxy derivatives of propranolol for immu

Chemistry: analytical and immunological testing – Involving immune complex formed in liquid phase – Separation of immune complex from unbound antigen or antibody

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436518, 436536, 436545, 436547, 436804, 424 857, 530387, 530806, G01N 3353

Patent

active

047957158

ABSTRACT:
Derivatives of propranolol which have the following structure: ##STR1## where R is X--(CH.sub.2).sub.n --O, X is NH.sub.2 or COOH, n is 1,2,3,4, or 5, provided that when n is 1, X must be COOH, and R is attached in the 4',5',6',7' or 8' position. The compounds are useful in immunoassay applications to (1) conjugate to a protein carrier in order to prepare antibodies to propranolol and (2) to conjugate to a tracer moiety such as a radiolabeled ligand, an enzyme, an enzyme substrate or a fluorescent dye.

REFERENCES:
patent: 4026879 (1977-05-01), Spector
patent: 4241177 (1980-12-01), Simgh et al.

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