Chemistry: analytical and immunological testing – Involving immune complex formed in liquid phase – Separation of immune complex from unbound antigen or antibody
Patent
1986-10-03
1989-01-03
Warden, Robert J.
Chemistry: analytical and immunological testing
Involving immune complex formed in liquid phase
Separation of immune complex from unbound antigen or antibody
436518, 436536, 436545, 436547, 436804, 424 857, 530387, 530806, G01N 3353
Patent
active
047957158
ABSTRACT:
Derivatives of propranolol which have the following structure: ##STR1## where R is X--(CH.sub.2).sub.n --O, X is NH.sub.2 or COOH, n is 1,2,3,4, or 5, provided that when n is 1, X must be COOH, and R is attached in the 4',5',6',7' or 8' position. The compounds are useful in immunoassay applications to (1) conjugate to a protein carrier in order to prepare antibodies to propranolol and (2) to conjugate to a tracer moiety such as a radiolabeled ligand, an enzyme, an enzyme substrate or a fluorescent dye.
REFERENCES:
patent: 4026879 (1977-05-01), Spector
patent: 4241177 (1980-12-01), Simgh et al.
Eller Thomas D.
Knapp Daniel R.
Benson Robert
Drug Science Foundation
Warden Robert J.
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