Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1990-03-09
1993-03-16
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
546225, 546227, 548536, 548537, 548538, 548953, A61K 3702, C07K 506, C07K 508, C07K 510
Patent
active
051945886
ABSTRACT:
The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.
REFERENCES:
patent: 4596789 (1986-06-01), Dutta et al.
Biochemistry (1986) 24 pp. 3760-3767.
Chem. Abstr; vol. 92 (1980) 175119.
Chem. Abstr., vol. 102 (1985) 84468.
Imperiali, B. and Abeles, R. H. Biochemistry (1986), 25, 3760 (including twenth (20) pages of supplementary material).
Imperiali, B. and Abeles, R. H. Tetrahedron Lett. (1986) 27, 135.
Edwards Philip D.
Schwartz John A.
Stein Mark M.
Trainor Diane A.
Wildonger Richard A.
ICI Americas Inc.
Jackson Thomas E.
Lee Lester L.
Miano Rosemary M.
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