Aminoalcohol derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S567000, C546S334000

Reexamination Certificate

active

07629366

ABSTRACT:
The present invention relates to a compound formula [I]:wherein ect.,X is bond, —CH2—, etc.,Y is bond, —O—(CH2)n— (in which n is 1, 2, 3 or 4), etc.,Z is cyano, tetrazolyl, etc.,R1is hydrogen, lower alkyl, etc.,R2is hydrogen or an amino protective group,R3is hydrogen or lower alkyl,R4is hydrogen or lower alkyl,R5and R8are each independently hydrogen, halogen, hydroxy, lower alkyl, etc.,R6is hydrogen, lower alkyl, etc.,R9is hydrogen or lower alkyl, andi is 1 or 2,or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.

REFERENCES:
patent: 5232946 (1993-08-01), Hurnaus et al.
patent: 7417060 (2008-08-01), Hattori et al.
patent: 2004/0106653 (2004-06-01), Sakurai et al.
patent: 2005/0137236 (2005-06-01), Hattori et al.
patent: 2 305 665 (1997-04-01), None
patent: WO 90/06299 (1990-06-01), None
patent: WO 02/32897 (2002-04-01), None
patent: WO 03/042164 (2003-05-01), None
Hurnaus et al. “Preparation of new phenylethanolamines . . . ” CA 111:77643 (1989).
Hattori et al. “Preparation of . . . ” CA 140:93927 (2004).
Hattori et al. “Preparation of biphenyl . . . ” CA 143:78089 (2005).
Hurnaus et al. “Preparation of new phenylethanolamines . . . ” CA 111:77643 (1989).
Shuker et al. “The application of high throughput . . . ” CA 127:277798 (1997).
Greene “Protective groups in organic synthesis” p. 154, 187-188 (1982).
Fisher et al. “Substituted phenylsulfonamides . . . ” CA 124:116877 (1995).
Brazzel et al. “Treatment of glaucoma . . . ” CA 126:1213 (1996).
Taniguchi et al. “Preparation of diaryalkylaminoalkanols . . . ” CA 132:194184 (2000).
U.S. Appl. No. 11/547,847, filed Oct. 6, 2006, Hattori, et al.

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