Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1982-05-18
1983-12-20
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125E, A61K 3700, C07C10352
Patent
active
044217447
ABSTRACT:
Peptide and pseudopeptide derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 stand for defined hydrocarbyl or halo-hydrocarbyl substituents, for example alk-2-enyl radicals; .dbd.N--A-- stands for a defined amino acid residue; B, D and E, which may be the same or different, stand for a valency bond or a defined amino acid residue; F stands for a defined amino acid residue; X stands for a carboxy, ester or amide group; and the linkages between the amino acid residues are peptide linkages or at least one of said linkages is a defined pseudo linkage; and pharmaceutically-acceptable salts thereof. Processes for the manufacture of the compounds. Pharmaceutical compositions comprising one of the compounds and a pharmaceutical diluent or carrier. The compounds are antagonists at the opiate receptors, and most of them are selective .delta.-receptor antagonists.
REFERENCES:
patent: 4148785 (1979-04-01), Dheer et al.
patent: 4148786 (1979-04-01), Sarantakis
patent: 4178371 (1979-12-01), Morgan
patent: 4199568 (1980-04-01), Rance et al.
patent: 4216127 (1980-08-01), Sarantakis
patent: 4216128 (1980-08-01), Sarantakis
patent: 4254106 (1981-03-01), Wilkinson
patent: 4261888 (1981-04-01), Bauer et al.
patent: 4278596 (1981-07-01), Garsky
patent: 4320051 (1982-03-01), Sarantakis
patent: 4322340 (1982-03-01), Shuman et al.
patent: 4322342 (1982-03-01), Smithwick, Jr. et al.
Imperial Chemical Industries plc
Phillips Delbert R.
LandOfFree
Aminoacyl derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aminoacyl derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminoacyl derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-107296