Amino thiol peptides

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.

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530800, C07K 5506, C07K 5508

Patent

active

046365605

ABSTRACT:
Analgesic and hypotensive activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl, carboxyalkyl, halo substituted alkyl, hydroxyalkyl, aminoalkyl, mercaptoalkyl, alkylthioalkyl, (cycloalkyl)alkyl, (heteroaryl)alkyl, arylalkyl, carbamoylalkyl, guanidinylalkyl, or heteroaryl;

REFERENCES:
patent: 4500518 (1985-02-01), Gordon
H. Umezawa et al., J. Antibiotics, vol. 29, p. 97 (1976).
H. Suda et al., J. Antibiotics, vol. 29, p. 100 (1976).
T. Aoyagi et al., J. Antibiotics, vol. 31, p. 636 (1978).
H. Tobe et al., Agric. Biological Chemistry, vol. 43, p. 591 (1979).
G. W. Wagner et al., J. Neurochem., vol. 37, p. 709 (1980).
Chan, W.-C., Biochemical and Biophysical Res. Comm., vol. 116, p. 297 (1983).

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