Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1984-11-16
1987-01-13
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
530800, C07K 5506, C07K 5508
Patent
active
046365605
ABSTRACT:
Analgesic and hypotensive activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl, carboxyalkyl, halo substituted alkyl, hydroxyalkyl, aminoalkyl, mercaptoalkyl, alkylthioalkyl, (cycloalkyl)alkyl, (heteroaryl)alkyl, arylalkyl, carbamoylalkyl, guanidinylalkyl, or heteroaryl;
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H. Suda et al., J. Antibiotics, vol. 29, p. 100 (1976).
T. Aoyagi et al., J. Antibiotics, vol. 31, p. 636 (1978).
H. Tobe et al., Agric. Biological Chemistry, vol. 43, p. 591 (1979).
G. W. Wagner et al., J. Neurochem., vol. 37, p. 709 (1980).
Chan, W.-C., Biochemical and Biophysical Res. Comm., vol. 116, p. 297 (1983).
Delaney Norma G.
Godfrey Jr. Jollie D.
Gordon Eric M.
Barrack Donald J.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Phillips Delbert R.
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