Amino thiol dipeptides

Details Amino thiol dipeptides Amino thiol dipeptides

1984-04-19

1985-02-19

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

546245, 546146, 548180, 548470, 548356, 548492, 2601125R, H61K 3700, A01N 4350, A01N 4336, C07D23100, C07D21160, C07D21700, C07C10352

Patent

active

045005184

ABSTRACT:
Amino thiol substituted dipeptides of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.

REFERENCES:
patent: 4329473 (1982-05-01), Almquist et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4470973 (1984-09-01), Natarajan et al.
Meyer et al., "Angiotensin Converting Enzyme Inhibitors . . . " J. Med. Chem., vol. 25, pp. 996-999 (1982).

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