Amino-terminally truncated MCP-2 as chemokine antagonists

Details Amino-terminally truncated MCP-2 as chemokine antagonists Amino-terminally truncated MCP-2 as chemokine antagonists

2005-05-06

2008-03-04

Mertz, Prema (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

C530S324000

Reexamination Certificate

active

07338653

ABSTRACT:
The present invention relates to amino-terminally truncated MCP-2, lacking NH2-terminal amino acids corresponding to amino acid residues 1, 1-2, 1-3, 1-4 or 1-5 of the naturally-occurring MCP-2 and having chemokine antagonistic activity, as well as cDNA sequences encoding them, their use in therapy and/or in diagnosis of the diseases, in which an antagonistic activity of the chemokine effects is required, and pharmaceutical compositions comprising them.

REFERENCES:
patent: 5739103 (1998-04-01), Rollins et al.
patent: WO 97/25427 (1997-07-01), None
Sozzani et al.,Journal of Immunology, 3615-3622 (1994).
Proudfoot et al.,Journal of Biological Chemistry, 271(5):2599-2603 (1996).
Proost et al.,Biochemistry, 32:10170-10177 (1993).
Proost et al.,Journal of Immunology, 150(3):1000-1010 (1993).
Proost et al.,Methods A companion to Methods in Enzymology, 10:82-92 (1996).
Proost et al.,Cytokine, 7(2):97-104 (1995).
Grynkiewicz et al.,Journal of Biological Chemistry, 260(6):3440-3450 (1985).
De Meester et al.,Journal of Immunological Methods, 189:99-105 (1996).
Clark-Lewis et al.,Journal of Biological Chemistry, 266(34):23-128-23134 (1991).
Chang et al.,International Immunology, 1(4):388-397 (1989).
Baggiolini et al.,Advances in Immunology, 55:97-179 (1994).
Van Damme et al.,J. Exp. Med., 176:59-65 (1992).
Weber et al.,J. Exp. Med., 183:681-685 (1996).
Gong et al.,Journal of Biological Chemistry, 271(18):10521-10527 (1996).
Gong et al.,J. Exp. Med., 181:631-640 (1995).
Van Damme et al.,Eur. J. Immunol., 20:2113-2118 (1990).
Van Damme et al.,Eur. J. Biochem., 181:337-344 (1989).
Van Coillie et al.,Biochemical and Biophysical Research Communications, 231:726-730 (1997).
Baggiolini et al.,Annual Review of Immunology, 15:675-705 (1997).
Zhang et al.,Journal of Biological Chemistry, 269(22):15918-15924 (1994).
Zhang et al.,METHODS: A Comparison To Methods in Enzymology, 10:93-103 (1996).
Zhang et al.,Molecular and Cellular Biology, 15(9):4851-4855 (1995).
Van Coille et al.,Genomics, 40:323-331 (1997).
Schols et al.,J. Exp. Med., 186(8):1383-1388 (1997).
Deng et al.,Nature, 381:661-666 (1996).
Wuyts et al.,Biochemistry, 36:2716-2723 (1997).
Taub,Cytokine&Growth Factor Reviews, 7(4):355-376 (1996).
Walz et al.,Biochemical and Biophysical Research Communications, 159(3):969-975 (1989).
Proost et al.,J. Immunol., 160:4034-4041 (1998).

Affiliated with

Also associated with

Rating

Amino-terminally truncated MCP-2 as chemokine antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amino-terminally truncated MCP-2 as chemokine antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amino-terminally truncated MCP-2 as chemokine antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3976243