Amino-terminally truncated MCP-2 as chemokine antagonists

Details Amino-terminally truncated MCP-2 as chemokine antagonists Amino-terminally truncated MCP-2 as chemokine antagonists

2005-06-14

2005-06-14

Mertz, Prema (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

C530S324000

Reexamination Certificate

active

06905676

ABSTRACT:
The present invention relates to amino-terminally truncated MCP-2, lacking NH2-terminal amino acids corresponding to amino acid residues 1, 1-2, 1-3, 1-4 or 1-5 of the naturally-occurring MCP-2 and having chemokine antagonistic activity, as well as cDNA sequences encoding them, their use in therapy and/or in diagnosis of the diseases, in which an antagonistic activity of the chemokine effects is required, and pharmaceutical compositions comprising them.

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