[Amino sulfonyl-2-oxo-nicotinyl]derivatives of cephalosporin

Details [Amino sulfonyl-2-oxo-nicotinyl]derivatives of cephalosporin [Amino sulfonyl-2-oxo-nicotinyl]derivatives of cephalosporin

1977-10-27

1979-01-30

Tovar, Jose

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 21, C07D50134

Patent

active

041374088

ABSTRACT:
Novel organic amide compounds which are N-[6-[(aminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinyl]penicillin and cephalosporin type compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or cephalosporin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[(aminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid, 7-aminocephalosporanic acid, 7-amino-3-methylceph-3-em-4-carboxylic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(aminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

REFERENCES:
patent: 4006230 (1977-02-01), Cox et al.
patent: 4053470 (1977-10-01), Doub et al.

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