Amino-substituted heterocycles as renin inhibitors

Details Amino-substituted heterocycles as renin inhibitors Amino-substituted heterocycles as renin inhibitors

1993-03-26

1995-09-26

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530335, C07K 102, C07K 106

Patent

active

054534887

ABSTRACT:
The invention concerns novel renin-inhibitory compounds which contain an amino-substituted heterocycle at the P.sub.2 position. These are useful for treating renin-associated hypertension, congestive heart failure, glaucoma, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the compounds, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, or hyperaldosteronism.

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Plattner et al., J. Med. Chem., vol. 31 (1988) #12 pp. 2277--2283.
Gross, E. "The Peptides, Analysis, Synthesis, Biology" vol. 3: Protection of Functional Groups in Peptide Synthesis (1981) see p. 25.
Bodanszky, Int. J. Peptide and Prot. Res. 25 (1985) pp. 449-474.

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