Amino-substituted heterocycles as renin inhibitors

Details Amino-substituted heterocycles as renin inhibitors Amino-substituted heterocycles as renin inhibitors

1990-04-25

1993-08-24

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 514359, 530331, 5483315, 5483147, 5483124, A61K 3702, A61K 3141, C07K 506, C07D23366

Patent

active

052389235

ABSTRACT:
The invention concerns novel renin-inhibitory compounds which contain an amino-substituted heterocycle at the P.sub.2 position. These are useful for treating renin-associated hypertension, congestive heart failure, glaucoma, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the compounds, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, or hyperaldosteronism.

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E. Haber et al., J. of Cardiovascular Pharmacology 10 (Suppl. 7): 554-558, 1987.
J. Med. Chem., vol. 30, 1987 pp. 1224-1228.

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