Amino-substituted dihydropyrimido[4,5-D]pyrimidinone...

Details Amino-substituted dihydropyrimido[4,5-D]pyrimidinone... Amino-substituted dihydropyrimido[4,5-D]pyrimidinone...

2006-08-15

2006-08-15

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S118000, C544S230000, C546S019000, C514S234200, C514S262100

Reexamination Certificate

active

07091345

ABSTRACT:
Compounds of formula Iare described. These compounds are protein kinase inhibitors, in particular they inhibit the src family tyrosine kinases. Thus, these compounds are useful for the treatment of diseases mediated by src tyrosine kinases, including cell proliferative disorders such as cancer. Also described are methods of making and using compounds of formula I as well as pharmaceutical compositions containing these compounds.

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