Amino substituted diaryl[ a,d ]cycloheptene analogs as...

Details Amino substituted diaryl[ a,d ]cycloheptene analogs as... Amino substituted diaryl[ a,d ]cycloheptene analogs as...

2006-05-03

2009-02-17

Coleman, Brenda L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S587000

Reexamination Certificate

active

07491715

ABSTRACT:
Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuropsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.

REFERENCES:
patent: 3389139 (1968-06-01), Schmutz et al.
patent: 3412193 (1968-11-01), Coppola
patent: 3444169 (1969-05-01), Howell et al.
patent: 3501483 (1970-03-01), Howell et al.
patent: 3532702 (1970-10-01), Howell et al.
patent: 3539573 (1970-11-01), Schmutz et al.
patent: 3546226 (1970-12-01), Hunziker et al.
patent: 3660406 (1972-05-01), Howell et al.
patent: 3663696 (1972-05-01), Howell et al.
patent: 3751415 (1973-08-01), Schmutz et al.
patent: 3758479 (1973-09-01), Schmutz et al.
patent: 3761481 (1973-09-01), Nakanishi et al.
patent: 3811026 (1974-05-01), Kaplan et al.
patent: 3852446 (1974-12-01), Schmutz et al.
patent: 3884920 (1975-05-01), Schmutz et al.
patent: 3908010 (1975-09-01), Schmutz et al.
patent: 3962248 (1976-06-01), Schneider
patent: 3983234 (1976-09-01), Sayers
patent: 4045445 (1977-08-01), Hardy, Jr. et al.
patent: 4096261 (1978-06-01), Horrom et al.
patent: 4097597 (1978-06-01), Horrom et al.
patent: 4191760 (1980-03-01), Horrom et al.
patent: 4243805 (1981-01-01), Protiva et al.
patent: 4263207 (1981-04-01), Rokach et al.
patent: 4308207 (1981-12-01), Hunziker et al.
patent: 4404137 (1983-09-01), Chakrabarti et al.
patent: 4406900 (1983-09-01), Hunziker et al.
patent: 4663453 (1987-05-01), Glamkowski
patent: 5300422 (1994-04-01), Gerson et al.
patent: 5344828 (1994-09-01), Sawanishi et al.
patent: 5354747 (1994-10-01), Hansen, Jr. et al.
patent: 5393752 (1995-02-01), Liegeois et al.
patent: 5538965 (1996-07-01), Tehim et al.
patent: 5602120 (1997-02-01), Fu et al.
patent: 5602121 (1997-02-01), Fu
patent: 5602124 (1997-02-01), Tehim et al.
patent: 5700445 (1997-12-01), Fu et al.
patent: 5707798 (1998-01-01), Brann
patent: 5814628 (1998-09-01), Fu et al.
patent: 5817655 (1998-10-01), Chakrabarti et al.
patent: 5834459 (1998-11-01), Fu
patent: 5962664 (1999-10-01), Friedhoff et al.
patent: 5968478 (1999-10-01), Fu et al.
patent: 6479488 (2002-11-01), Di-Fabio et al.
patent: 6566065 (2003-05-01), Rozen
patent: 6630462 (2003-10-01), DeHaven et al.
patent: 2002/0037886 (2002-03-01), Andersson et al.
patent: 2004/0224942 (2004-11-01), Weiner et al.
patent: 2005/0085463 (2005-04-01), Weiner et al.
patent: 2005/0192268 (2005-09-01), Ek et al.
patent: 2005/0250767 (2005-11-01), Weiner et al.
patent: 2005/0282800 (2005-12-01), Tolf et al.
patent: 2006/0063754 (2006-03-01), Edgar et al.
patent: 2006/0063755 (2006-03-01), Edgar et al.
patent: 2006/0069083 (2006-03-01), Steiner et al.
patent: 2006/0111342 (2006-05-01), Argentine et al.
patent: 2006/0194784 (2006-08-01), Ek et al.
patent: 2006/0194831 (2006-08-01), Weiner et al.
patent: 2006/0199798 (2006-09-01), Ek et al.
patent: 2006/0199807 (2006-09-01), Weiner et al.
patent: 2006/0199808 (2006-09-01), Tolf et al.
patent: 2006/0205714 (2006-09-01), Tolf et al.
patent: 2006/0233843 (2006-10-01), Conn et al.
patent: 2006/0252744 (2006-11-01), Burstein
patent: 2007/0105836 (2007-05-01), Pettersson et al.
patent: 2007/0197502 (2007-08-01), Ek et al.
patent: 2007/0275957 (2007-11-01), Weiner et al.
patent: 240 228 (1945-12-01), None
patent: 422 793 (1966-10-01), None
patent: 436 297 (1967-05-01), None
patent: 476 753 (1969-08-01), None
patent: 493 538 (1970-07-01), None
patent: 499 539 (1970-11-01), None
patent: 517 759 (1972-01-01), None
patent: 585 222 (1977-02-01), None
patent: 601 288 (1978-07-01), None
patent: 0179793 (1977-11-01), None
patent: 2316438 A18 (1973-10-01), None
patent: 24 13 610 (1974-10-01), None
patent: 26 25 258 (1976-12-01), None
patent: 133 235 (1978-12-01), None
patent: 0 240 228 (1987-10-01), None
patent: 1 726 952 (2006-11-01), None
patent: 870 763 (1942-03-01), None
patent: 939 595 (1948-11-01), None
patent: 1 334 944 (1963-08-01), None
patent: 51 (1964-04-01), None
patent: 2 222 102 (1974-10-01), None
patent: 1 006 156 (1965-09-01), None
patent: 1 164 360 (1969-09-01), None
patent: 1 177 956 (1970-01-01), None
patent: 1 177 957 (1970-01-01), None
patent: 1 216 523 (1970-12-01), None
patent: 1 218 045 (1971-01-01), None
patent: 1 355 866 (1974-06-01), None
patent: 1 418 363 (1975-12-01), None
patent: 1 554 275 (1979-10-01), None
patent: 2 292 685 (1996-03-01), None
patent: WO 93/07143 (1993-04-01), None
patent: WO 95/17400 (1995-06-01), None
patent: WO 96/18621 (1996-06-01), None
patent: WO 96/18623 (1996-06-01), None
patent: WO 96/18629 (1996-06-01), None
patent: WO 96/29316 (1996-09-01), None
patent: WO 99/50247 (1999-10-01), None
patent: WO 01/29036 (2001-04-01), None
patent: WO 01/83472 (2001-11-01), None
patent: WO 02/060870 (2002-08-01), None
patent: WO 03/000670 (2003-01-01), None
patent: WO 03/070249 (2003-08-01), None
patent: WO 03/082877 (2003-10-01), None
patent: WO 2004/026030 (2004-04-01), None
patent: WO 2004/056182 (2004-07-01), None
patent: WO 2004/064738 (2004-08-01), None
patent: WO 2004/064753 (2004-08-01), None
patent: WO 2004/073639 (2004-09-01), None
patent: WO 2004/078216 (2004-09-01), None
patent: WO 2005/002586 (2005-01-01), None
patent: WO 2005/063254 (2005-07-01), None
patent: WO 2005/103041 (2005-11-01), None
patent: WO 2006/017614 (2006-02-01), None
patent: WO 2006/034414 (2006-03-01), None
patent: WO 2006/049734 (2006-05-01), None
patent: WO 2006/081327 (2006-08-01), None
patent: WO 2006/088786 (2006-08-01), None
patent: WO 2006/107948 (2006-10-01), None
patent: WO 2007/062336 (2007-05-01), None
patent: WO 2007/062337 (2007-05-01), None
patent: WO 2007/062338 (2007-05-01), None
patent: WO 2007/062339 (2007-05-01), None
patent: WO 2008/002602 (2008-01-01), None
patent: WO 2008/066620 (2008-05-01), None
Alves-Rodriques A, Leurs R, Willems E and Timmerman H (1996). Binding of clozapine metabolites and analogues to the histamine H3 receptor in rat brain cortex.Archiv der Pharmazie, 329: 413-416.
Anonymous, Certificate of Analysis: N-Desmethylclozapine (2003), Internet article, Database accession No. 2003: 2066817, Order No. D292000.
Anonymous, Morphanthridine. Research Disclosure, 258:512-14 (1985).
Anonymous, Piperazinyldibenzazepine. Research Disclosure, 192:158-9 (1980).
Ashby, C.R. et al., Pharmacological actions of the atypical antipsychotic drug clozapine: A review, Synapse, 24:349-394 (1996).
Baldessarini RJ, Centorrino F, Flood JG, Volpicelli SA, Huston-Lyons D and Cohen BM (1993). Tissue concentrations of clozapine and its metabolite in the rat.Neuropsychopharm, 9: 117-124.
Baldessarini, R., J., and Frankenburg, F., R. (1991) Clozapine. A novel antipsychotic agent.New Engl. J. Med., 324(11): 746-754.
Baumeister AA, Francis JL. Historical development of the dopamine hypothesis of schizophrenia.J Hist Neurosci.Sep. 2002;11(3):265-77.
Berkeley JL and Levey AI (2003). Cell-Sepcific Extracellular Signal-regulated Kinase Activation by Multiple G Protein-coupled receptor Families in Hippocampus.Mol Pharm, 63: 128-135.
Berkeley JL, Gomeza J, Wess J, Hamilton SE, Nathanson NM and Levey AI (2001). M1 Muscarinic Acetylcholine Receptors Activate Extracellular Signal-Regulated Kinase in CA1 Pyramidal Neurons in Mouse Hippocampal Slices.Mol Cell Neurosci, 18: 512-524.
Birdsall, N.J.M. et al., Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: Functional studies, Molecular Pharmacology, 55(4):778-786 (1999).
Bodick NC, Offen WW. Levey AI, Cutler NR, Gauthier SG, Satlin A, Shannon HE, Tollefson GD, Rasmussen K, Bymaster FP, Hurley DJ, Potter WZ, Paul SM (1997) Effects of xanomeline, a selective nuscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease.Arch Neurol54:465-473.
Bolden C, Cusack B, Richelson E (1991) Clozapine is a potent and selective muscarinic antagonist at the five cloned human muscarinic acetylcholine receptors expressed in CHO-K1 cells,Eur J Pharmacol192:205-206.
Bondesson U, Lindstrom LH (1988) Determination of clozapine and its N-demethyla

Affiliated with

Also associated with

Rating

Amino substituted diaryl[ a,d ]cycloheptene analogs as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amino substituted diaryl[ a,d ]cycloheptene analogs as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amino substituted diaryl[ a,d ]cycloheptene analogs as... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4100154