Amino-substituted benzenesulfonylureas and -thioureas and their

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514255, 514331, 514429, 514584, 514592, 5142275, 544 581, 544159, 544160, 544393, 546231, 548577, 564 23, 564 41, A61K 3164, C07C31158, C07D295155

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054768500

ABSTRACT:
There are described amino-substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## The compounds I are used for the treatment of cardiac arrhythmias and for the prevention of sudden heart death caused by arrhythmias and can therefore be used as antiarrhythmics. They are particularly suitable for those cases in which arrhythmias are a result of constriction of a coronary vessel, such as in angina pectoris or in acute cardiac infarct.

REFERENCES:
patent: 3998968 (1976-12-01), Hitzel et al.
Derwent Abstract of German Patent DE 1,518,874, Jul. 18, 1974.
L. H. Opie, "Modulation of Ischemia By Regulation Of The ATP-Sensitive Potassium Channel" Cardiovascular Drugs and Therapy, No. 7, pp. 507-513 (1993).

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