Amino-substituted 8-N-benzimidazoles and methods for their...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S199000

Reexamination Certificate

active

08003668

ABSTRACT:
The present invention comprises the use of amino-substituted 8-N-benzimidazoles compounds of formula Iwherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-lowering action. These compounds are intended to be particularly suitable in the treatment of diabetes.

REFERENCES:
patent: 1069124 (2001-01-01), None
patent: WO 97/12615 (1997-04-01), None
patent: WO 03/104233 (2003-12-01), None
Setoi et al. “preparation of heteocy . . . ” CA 131:116236 (1999).
Baradi et al. “Novel 8-heterocycl . . . ” Exp. Opin.Drg. Dis. 2(9) 1161-1183 (2007).
Gupta et al. “Emerging drug . . . ” Cur. Drug. target 10, 71-87 (2009).
McIntosh et al. “application of DPP IV . . . ” Int. J. Biochem. Cell Biol. 38, p. 860-872 (2006).
Hypoglycemia Wikipedia p. 1-12 from internet (2010)I.
Sitagliptin Wikipedia p. 1-3 (2010).
Jordan, V. C. Nature Reviews: Drug Discovery, 2, pp. 205-213 (2003).

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