Amino-phthalazinone derivatives active as kinase inhibitors,...

Details Amino-phthalazinone derivatives active as kinase inhibitors,... Amino-phthalazinone derivatives active as kinase inhibitors,...

2002-07-30

2008-10-07

Wilson, James (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S251000, C544S237000, C506S015000, C549S216000, C549S304000, C546S283100

Reexamination Certificate

active

07432263

ABSTRACT:
Compounds which are amino-phthalazinone derivatives according to formula 1 and pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compostions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, autoimmune diseases and neurodegenerative disorders.

REFERENCES:
patent: 0600831 (1994-06-01), None
patent: 0634404 (1995-01-01), None
patent: 871753 (1961-06-01), None
patent: 09061961 (1997-03-01), None
patent: 10287658 (1998-10-01), None
patent: WO 98/35958 (1998-08-01), None
patent: WO 0061556 (2000-10-01), None
Clare, et al., J. Biol. Chem., vol. 276, No. 51, Dec. 21, 2001, pp. 48292-48299.
Georgieva, et al., J. Clin. Pathol. 2001; 54:229-235.
Takahashi, et al., Mol. Cancer Ther., 2005,; 4(7), Jul. 2005.
Attached printout from the Leukemia & Lymphoma Society website, <http://www.leukemia-lymphoma.org/all—page?item—id=7026>, downloaded Jul. 12, 2007.
Printout from the Leukemia & Lymphoma Society website, <http://www.leukemia-lymphoma.org/all—page?item—id=7030&viewmode=print>, downloaded Jul. 13, 2007.
Printout on viral infections from the Medline Plus website, <http://www.nlm.nih.gov/medlineplus/viralinfections.html>, downloaded Jul. 12, 2007.
Attached printout from the Johns Hopkins Medical Institutions website, <http://autoimmune.pathology.jhmi.edu/diseases.cfm.> downloaded Jul. 16, 2007.
Disorders Index of the National Institute of Neurological Disorders and Stroke, http://www.ninds.nih.gov/disorders/disorder—index.htm?css=print, (NINDS Index).
Patton, et al., J. Pharmacol & Exp. Therap., vol. 239, No. 2, pp. 597-605.
Blain, et al., J. of Biol. Chem., vol. 272,, No. 41, Oct. 10, 1997, 25863-25872.
BBC News/Health, Killer Breast Cancer Therapy Hope, <http:/
ewsvote.bbc.co.uk/mpapps/pagetooles/print
ews.bbc.co.uk/1/hi/health/4619900.stm>, downloaded Jan. 31, 2007.
Masuda, et al., Oncogene (Feb. 20, 2003) 22, 1012-1023.
Ito, et al., Anticancer Research, 2004, Vo. 24, No. 1, pp. 259+ (Abstract).
Mito, et al., Leuk. Lymphoma, Feb. 2005, 46(2): 225+ (PubMed abstract).
Verschuren, et al., J. Gen. Virology (2004), 85, 1347-1361.
(<<http://www.uspto.gov/web/offices/pac/dapp/1pecba.htm#7>> Enablement Decision Tree, Example F, situation 1.
Viral Defense Found., <http://www.viraldefense.org/mission.htm>, downloaded May 23, 2007.
Visiting Nurse Assns. of America, <http://www.vnaa.org/vnaa/gen/Germ—Protection—Center—Cold—and—Flu—Resources,html...>, downloaded May 23, 2007.
Printout from the Wikipedia website < http://en.wikipedia.org/wiki/Derivative—%28chemistry%29> providing a chemical definition of “derivative,” downloaded Jul. 21, 2007.
Philip Cohen,The Development and Therapeutic Potential of Protein Kinase Inhibitors, Current Opinion in Chemical Biology, vol. 3, pp. 459-465, (1999).
S. S. Berg,Bisquaternary Salts Related to Quinapyramine(Antrycide)Replacement of the Quinoline Nucleus by Other Heterocycles, Journal of Chem Soc. pp. 5275-5284, (1961).
Brian D. Palmer,Structure-Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor, Journal of Medical Chemistry, vol. 42, pp. 2373-2382, (1999).

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