Amino- or guanidino-1,2,3,4-tetrahydro-1-naphthoic esters

Details Amino- or guanidino-1,2,3,4-tetrahydro-1-naphthoic esters Amino- or guanidino-1,2,3,4-tetrahydro-1-naphthoic esters

1979-04-16

1980-07-22

Breitenstein, G. T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260465D, 424309, 560 21, 560 45, 560 48, C07C10148, A61K 3124

Patent

active

042140935

ABSTRACT:
Amino- or guanidino-1,2,3,4-tetrahydro-1-naphthoic esters represented by the formula, ##STR1## wherein R.sub.1 is --NH.sub.2 or ##STR2## R.sub.3 is --H, --R.sub.4, --O--R.sub.4, --NHCOCH.sub.3, a halogen, --CN, ##STR3## --COOH, --COOR.sub.4, ##STR4## or --(CH.sub.2).sub.n --COOCH.sub.2 --CO--R.sub.5 ; R.sub.5 is --O--R.sub.4, --NH.sub.2 or ##STR5## n is 0, 1 or 2, and R.sub.4 is a lower alkyl, or pharmaceutically acceptable acid addition salts thereof. Owing to their inhibitory activity on proteolytic enzymes the said esters and acid addition salts thereof are useful in the therapy of diseases caused by such enzymes.

REFERENCES:
Sergievskaya et al., Chem. Absts., 47, 8053(d), 1953.
Hohenlohe--Oehringen, Chem. Absts., 53, 7110(f), 1959.

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