Amino O-aryl macrolides having immunosuppressive activity

Details Amino O-aryl macrolides having immunosuppressive activity Amino O-aryl macrolides having immunosuppressive activity

1992-05-06

1993-11-16

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

514291, 514417, C07D49116, A61K 31395

Patent

active

052625338

ABSTRACT:
Amino O-aryl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by arylation and amination at C-3"/C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses. Also, these macrolides are useful in the treatment of reversible obstructive airways disease, particularly asthma; as hair revitalizing agents, especially in the treatment of male pattern alopecia or alopecia senilis; in the reversal of multidrug resistance of tumor cells; in treatment of inflammation of mucosa and blood vessels, gastric ulcers, vascular damage, ischemic bowel disease, inflammatory bowel disease, necrotizing enterocolitis, intestinal lesions associated with thermal burns; in the treatment of cytomegalovirus infection; and in the treatment of idiopathic thrombocytopenic purpura and Basedow's disease.

REFERENCES:
patent: 4894366 (1990-01-01), Okuhara et al.
patent: 4929611 (1990-05-01), Okuhara et al.
patent: 4956352 (1990-09-01), Okuhara et al.
patent: 4981792 (1991-01-01), Inamine et al.
patent: 5011844 (1991-04-01), Fehr
patent: 5064835 (1991-11-01), Bochis et al.
patent: 5110811 (1992-05-01), Okuhara et al.
patent: 5162334 (1992-11-01), Goulet et al.
Tanaka, et al., J. Am. Chem. Soc., 1987, 109 5031-5033.

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