Amino methyl imidazoles as C5a receptor modulators

Details Amino methyl imidazoles as C5a receptor modulators Amino methyl imidazoles as C5a receptor modulators

2007-01-30

2007-01-30

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S235500, C514S254080, C544S139000, C544S370000, C548S417000

Reexamination Certificate

active

10647191

ABSTRACT:
Amino methyl imidazoles of Formula I are provided:wherein R, R1, R2, R3, R4, R5, and R6are defined herein.Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. Additionally, this invention provides labeled amino methyl imidazoles compounds, which are useful as probes for the localization of C5a receptors.

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Loozen et al., “6-Aza-, 6-Oxa- and 6-Thia-4,5,6,7-Tetrahydrobenzimidazoles by Electrophilic Intramolecular Ring Closure of Imidazoles,”Department of Organic Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands, vol. 12, pp. 1039-1042 (1975).

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