Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to or within viable or inviable whole...
Reexamination Certificate
2011-08-30
2011-08-30
Saeed, Kamal (Department: 1626)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to or within viable or inviable whole...
C435S007930, C514S396000, C548S335100
Reexamination Certificate
active
08007767
ABSTRACT:
Amino methyl imidazoles of Formula I are provided:wherein R, R1, R2, R3, R4, R5, and R6are defined herein.Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. Additionally, this invention provides labeled amino methyl imidazoles compounds, which are useful as probes for the localization of C5a receptors.
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Loozen et al., “6-Aza-, 6-Xoa-and 6-Thia-4,5,6,7-Tetrahydrobenzimidazoles” Dept. of Org. Chem., Eindoven Univ of Tech, Eindhoven, The Netherlands, vol. 12, pp. 1039-1042 (1975).
Gao Yang
Thurkauf Andrew
Zhang Suoming
Zhao He
Corless Peter F.
Edwards Angell Palmer & & Dodge LLP
Kim Dwight D.
Novartis International Pharmaceutical Ltd.
Saeed Kamal
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