Amino-(hydroxy)alkoxy-4-phenylpropyl indoles having antiarrythmi

Details Amino-(hydroxy)alkoxy-4-phenylpropyl indoles having antiarrythmi Amino-(hydroxy)alkoxy-4-phenylpropyl indoles having antiarrythmi

1986-06-25

1989-02-28

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142352, 514253, 514323, 514418, 544143, 544144, 544373, 546201, 548469, 548486, A61K 3140, C07D20904

Patent

active

048086096

ABSTRACT:
A compound selected from the group consisting of hydroxyalkoxy-4-phenylpropyl-indoles of the formula ##STR1## wherein R and R.sub.1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms and aralkyl of 7 to 12 carbon atoms optionally substituted with 1 to 3 members of the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, --CF.sub.3, --NO.sub.2, CH.sub.3 S-- and --NH.sub.2 or R.sub.1 and R together with the nitrogen atom to which they are attached form an optionally unsaturated heterocycle optionally containing --S--, --O-- or ##STR2## R' is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, phenyl, naphthyl and phenylalkyl of 7 to 12 carbon atoms, a and b form =O and c is hydrogen or a and c form a carbon-carbon bond and b is hydrogen, the dotted line is an optional double bond, A is ##STR3## m is 1,2 or 3, R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, x is selected from the group consisting of hydrogen and --OH and y is hydrogen or x together with y is =O and their non-toxic, pharmaceutically acceptable acid addition salts having antiarrhythmic activity and blocking of slow calcico-sodic canals and a process and novel intermediates for their preparation.

REFERENCES:
patent: 4387100 (1983-06-01), Machin
patent: 4650811 (1987-03-01), Guillaume

Affiliated with

Also associated with

Rating

Amino-(hydroxy)alkoxy-4-phenylpropyl indoles having antiarrythmi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amino-(hydroxy)alkoxy-4-phenylpropyl indoles having antiarrythmi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amino-(hydroxy)alkoxy-4-phenylpropyl indoles having antiarrythmi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1367413