Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1988-07-08
1993-05-18
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
546 21, 548412, 558 81, 536 2534, C07D26530, C07F 906, C07F 9547
Patent
active
052123049
ABSTRACT:
The compounds of the invention include novel linking agents comprising 2-substituted-3-protected-1,3,2-oxazaphosphacycloalkanes and their phosphoramidite precursors. The compounds of the invention further include conjugates of the above linking agents with oligonucleotides and polymer supports. The compounds of the present invention are useful for linking organic moieties, such as fluorescent or chromogenic dyes, to polymer supports and oligonucleotides, particularly single- and double-stranded DNA and RNA fragments.
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Fung Steven
Smith Lloyd M.
Woo Sam L.
Applied Biosystems Inc.
Brown Johnnie R.
Crane L. Eric
Macevicz Stephen C.
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