Amino derivatives of chloro nitro amino pyrazines useful as adju

Details Amino derivatives of chloro nitro amino pyrazines useful as adju Amino derivatives of chloro nitro amino pyrazines useful as adju

1982-07-19

1983-11-29

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424250, 544405, 544120, 544359, A61K 31495, C07D24116, C07D24120

Patent

active

044180624

ABSTRACT:
2-Substituted amino derivatives of 6-amino-3-chloro-5-nitropyrazin-2-yl are prepared by converting 3-amino-5,6-dichloropyrazinecarboxylic acid to 5,6-dichloro-3-nitropyrazinamine and treating said compound with an amine to produce the corresponding 2-substituted amino compound.

REFERENCES:
patent: 3541093 (1970-11-01), Tull et al.
patent: 3660397 (1972-02-01), Jones et al.
Ainsworth, et al., Canadian J. Biochemistry 56: (1978) pp. 457-461.
Adams, et al., The Lancet, (Jan., 1976) pp. 186-188.
Olive, Peggy; Cancer Research vol. 39 (Nov. 1979) pp. 4512-4515.
Anderson, et al., British J. of Cancer, vol. 37, (1978) pp. 103-106.

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