Amino derivatives of 4-phenyl 4-oxobuten-2-oic acid, pharmaceuti

Details Amino derivatives of 4-phenyl 4-oxobuten-2-oic acid, pharmaceuti Amino derivatives of 4-phenyl 4-oxobuten-2-oic acid, pharmaceuti

1982-10-20

1984-12-04

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424853, 42424855, 424250, 424300, 424309, 424316, 424319, 544107, 544109, 544110, 544121, 544130, 544141, 544357, 544360, 544372, 544395, 544410, 544129, 546184, 546192, 548579, 560 12, 560 13, 560 19, 560 24, 560 25, 560 34, 562430, 562433, 562439, 26050111, 26050112, A01N 4384, A01N 4348, C07D26530, C07D29502, C07D41300, C07D24102

Patent

active

044864299

ABSTRACT:
Compounds of the formula I: ##STR1## in which R represents a hydrogen atom or an alkyl radical containing from 1 to 8 carbon atoms and R.sub.1 and R.sub.2, which may be identical or different independently represent a hydrogen atom, an alkyl radical containing from 1 to 4 carbon atoms, a --CONH.sub.2 radical, a --CO.sub.2 alk.sub.1 radical in which alk.sub.1 represents an alkyl radical containing from 2 to 8 carbon atoms, or an--SO.sub.2 alk.sub.2 radical in which alk.sub.2 represents an alkyl radical containing from 1 to 8 carbon atoms, or R.sub.1 and R.sub.2 together with the nitrogen atom form a heterocycle provided that R.sub.1 and R.sub.2 are not both hydrogen, as well as the alkali metal, alkaline earth metal, ammonium or amine salts of compounds of formula I in which R represents a hydrogen atom. These compounds are useful in treating hyperchlorhydria, gastric or gastroduodenal ulcers, gastritis, hiatal hernias and gastric or gastroduodenal ailments accompanied by gastric hyperacidity. The invention includes pharmaceutical compositions comprising compounds of formula (I) as well as methods of making the compounds.

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