Amino cyclobutylamide modulators of chemokine receptor activity

Details Amino cyclobutylamide modulators of chemokine receptor activity Amino cyclobutylamide modulators of chemokine receptor activity

2004-03-15

2009-06-30

Chang, Celia (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S017000

Reexamination Certificate

active

07553841

ABSTRACT:
The present invention is directed to compounds of the formulas I and II: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R25, R26, Y, Z, l, m, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

REFERENCES:
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patent: WO01/22919 (2001-04-01), None
patent: WO 02/13824 (2002-02-01), None
patent: WO 2004/110376 (2004-12-01), None
Abbadie et al. “CCR-2 antagonists . . . ” CA 142:69197 (2004).
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Cohen et al. “Cytokine function” Am. J. Clin. path. v.105(5) p. 589-598 (1996).
Yang et al. “Disovery of 2-piperidinyl . . . ” J. Med. Chem. v.50, p. 2609-2611 (1997).

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