Amino, cyano phenylthio or phenoxyl indole derivatives

Details Amino, cyano phenylthio or phenoxyl indole derivatives Amino, cyano phenylthio or phenoxyl indole derivatives

1983-10-24

1985-08-06

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548483, C07D20942

Patent

active

045336725

ABSTRACT:
This invention relates to indole derivatives which have anti-cancer activity. According to the invention there is provided an indole derivative of the formula I: ##STR1## in which X is an oxygen or sulphur atom, Ra is a phenyl radical which is optionally substituted by one or two groups selected from halogen atoms and 1-6C alkyl, 1-6C alkoxy and trifluoromethyl radicals and Rb is a hydrogen atom or a 2-6C alkoxycarbonyl radical. Manufacturing processes and pharmaceutical compositions are also described.

REFERENCES:
Atassi & Tagnon, European J. Cancer, 1975, 11, 599-607.
Gilman et al., J. Organic Chemistry, 1972, 37, 3201-3206.
Gewald & Hentschel, J. Prakt. Chem., 1976, 318, 663-670.
Aurich & Weiss, Annalen Chem., 1976, 432-439.
Miyadera et al., Chem. Pharm. Bull., 1981, 29, 2193-2198.
Shredor et al., "Synthesis . . . 2-Amino-3-Cyano-Tetrahydroindole," Chem. Abst. 84 (21): 150590r.

Affiliated with

Also associated with

Rating

Amino, cyano phenylthio or phenoxyl indole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amino, cyano phenylthio or phenoxyl indole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amino, cyano phenylthio or phenoxyl indole derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-512970