Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-05-02
2006-05-02
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S349000
Reexamination Certificate
active
07037911
ABSTRACT:
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel amino-bicyclic pyrazinone and pyridinone compounds of Formula (I):or a stereoisomer or pharmaceutically acceptable salt form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor Xa, factor XIa, factor IXa, and/or factor VIIa. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
REFERENCES:
patent: 5023236 (1991-06-01), Edgington et al.
patent: 5843442 (1998-12-01), Soule et al.
patent: 5859010 (1999-01-01), Petersen et al.
patent: 6277851 (2001-08-01), De Nanteuil et al.
patent: 6514997 (2003-02-01), Dragovich et al.
patent: 6686358 (2004-02-01), De Nanteuil et al.
patent: 2001/0047006 (2001-11-01), Dragovich et al.
patent: 2004/0006065 (2004-01-01), Glunz
patent: WO 95/35308 (1995-12-01), None
patent: WO 99/12034 (1999-03-01), None
patent: WO 01/64678 (2001-09-01), None
Sanderson, P.E.J. et al., “Efficacious Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates”, J. Med. Chem. vol. 41, pp. 4466-4474 (1998).
Kifle Bruck
Sum Jing G.
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