Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-12-07
1997-01-21
Burn, Brian M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514650, 514656, 514662, 564384, 564427, 564443, 564459, A61K 31135
Patent
active
055960200
ABSTRACT:
This invention relates to a class of novel amino bi- and tri-carbocyclic alkane compounds having bis-aryl substitution which exhibit squalene synthase inhibition properties. The bi- and tri-carbocyclic alkane ring contains an amino group and the ring is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
REFERENCES:
patent: 4100170 (1978-07-01), Shetty
Learn Keith S.
Morris Robert L.
Neuenschwander Kent W.
Scotese Anthony C.
Burn Brian M.
Nicholson James A.
Parker III Raymond S.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Savitzky Martin F.
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