Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-06-25
1995-03-07
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548217, 548219, 548221, 548222, 548224, 548110, 548156, 548159, 548454, 548455, 546147, 546167, 546180, 549390, 564161, 564308, 564455, 568375, A61K 3142, C07D26356
Patent
active
053958462
ABSTRACT:
This invention relates to a class of novel amino bi- and tri-carbocyclic alkane compounds having bis-aryl substitution which exhibit squalene synthase inhibition properties. The bi- and tri-carbocyclic alkane ring contains an amino group and the ring is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
REFERENCES:
patent: 4684658 (1987-08-01), Fabre et al.
patent: 4861897 (1989-08-01), Press et al.
patent: 5192798 (1993-03-01), Aiken et al.
Learn Keith S.
Morris Robert L.
Neuenschwander Kent W.
Scotese Anthony C.
Daus Donald G.
Nicholson James A.
Parker III Raymond S.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Savitzky Martin F.
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