Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-02-03
1996-05-07
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142315, 514248, 514314, 514399, 514400, 514535, 514561, 514563, 514567, 514617, 514634, 514632, A61K 31535, A61K 31495, A61K 31415, A61K 31195, A61K 31165, A61K 31155
Patent
active
055146767
ABSTRACT:
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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Cerami Anthony
Hwang San-Bao
Lankin Michael E.
Shih David H.
Ulrich Peter C.
Alteon Inc.
Criares Theodore J.
The Rockefeller University
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