Amino benzenepropanoic acid compounds and derivatives thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

562442, 562444, 562448, C07C22900

Patent

active

061004235

ABSTRACT:
The present invention is directed to compounds of the formula ##STR1## where R.sup.1 is BOC or H, R is H or lower alkyl; X and Y are the same or different halo atoms selected from the group consisting of Cl, Br or I and pharmaceutically acceptable salts and isomers thereof.

REFERENCES:
patent: 4677111 (1987-06-01), Haga et al.
patent: 5256812 (1993-10-01), Alig et al.
patent: 5273982 (1993-12-01), Alig et al.
patent: 5753230 (1998-05-01), Brooks et al.
patent: 5766591 (1998-06-01), Brooks et al.
K.C. Huang, J. Pharmacol. Exptl. THerap., vol. 121, (1957), pp. 443-448.
Shiba, Cahnmann, (J. Org. Chem. vol. 29, (1964), pp. 3063-3065.
Abderhalden, Schmitz (Fermentforschung, vol. 10, (1929), pp. 428-439.
Beckers C. et al. (Endocrinology, vol. 66, (1960), pp. 669-675.
Derwent Abstract #00305 K/01.
Derwent Abstract #57918 B/1.
Derwent Abstract #77105 E/37.
Derwent Abstract #87-009150/02.
Derwent Abstract #87-065042/10.
Derwent Abstract #89-055466/08.
Derwent Abstract #89-349943/48.
Derwent Abstract #92-398070/48.
Derwent Abstract #93-060253/08.
Derwent Abstract #93-08363/.
Derwent Abstract #93-127579/16.
Adamis, Anthony P. "Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Reinopathy", American Journal of Opthamology, vol. 118, pp. 445-450 (Oct. 1994).
Brooks, Peter C. et al. "Requirement for Vascular Integrin .alpha..sub.v--3 for Angiogenesis", Science, vol. 264, pp. 569-571 (Apr. 22, 1994).
Brooks, Peter C. et al. "Integrin .alpha..sub.v .beta..sub.3 Antagonists Promote Tumor Regression by nducing Apoptosis of Angiogenic Blood Vessels", Cell, vol. 79, pp. 1157-1164 (Dec. 30, 1994).
Choi, Eric T., et al. "Inhibition of Neointimal Hyperplasia by Blocking .alpha..sub.v .beta..sub.3 Integrin with a Small Peptide Antagonist Gpen GRDSPCA", Journal of Vascular Surgery, vol. 19 (1), pp. 125-133.
Clyman, Ronald I. et al. ".beta..sub.1 and .beta..sub.3 Integrens Have Different Roles in the Adhesion and Migration of Vascular Smooth Muscle Cells on Extracellular Matrix", Experimental Cell Research, vol. 200, pp. 272-284 (1992).
Liaw, Luct et al. "The Adhesive and Migratory Effects of Osteopontin are Mediated via Distinct Cell Surface Integrins:Role of .alpha..sub.v .beta..sub.3 in Smooth Muscle Migration to Osteopontin in Vitro", Journal of Clinical Investigation, vol. 95, pp. 713-724 (Feb. 1995).
Peacock, Derek J. et al. "Angiogenesis Inhibition Suppresses Collagen Arthritis", Journal of Experimental Medicine, vol. 175, pp. 1135-1138 (Apr. 1992).
Seftor, Richard E. B. et al. "Role of the .alpha..sub.v .beta..sub.3 Integrin in Human Melanoma Cell Invasion", Proceedings of the National Academy of Sciences U.S.A., vol. 89, pp. 1557-1561 (Mar. 1992).
Schnur, Rodney C. et al. "N-(5-Fluorobenzothiazaol-2-yl)-2-huanidinotiazole-4-carboxamide. A Novel, Systemically Active Antitumor Agent Effective Against 3LL Lewis Lung Carcinoma", Journal of Medicinal Chemistry, vol. 34 (3), pp. 914-918 (1991).
Schnur, Rodney C. et al. "Quantitative Structure-Activity Relationships of Antitumor Guanidinothiazolecarboxamides with Survival Enhancement for Therapy in the 3LL Lewis Lung Carcinoma Model", Journal of Medicinal Chemistry, vol. 34 (7), pp. 1975-1982 (1991).
Smith, Jeffery W. et al. "Interactions of Integrins .alpha..sub.v .beta..sub.3 and GlycoProtein IIb-IIIa with Fibrinogen", Journal of Biological Chemistry, vol. 265 (21), pp. 12267-12271 (Jul. 25, 1990).
White, Judith M. "Integrins as Virus Receptors", Current Biology, vol. 3 (9), pp. 596-599 9 (1993).
Yue, Tian-Li "Osteopontin-Stimulated Vascular Smooth Muscle Cell Migration Is Mediated by .beta..sub.3 Integrin", Experimental Cell Research, vol. 214, 459-464 (1994).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Amino benzenepropanoic acid compounds and derivatives thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amino benzenepropanoic acid compounds and derivatives thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amino benzenepropanoic acid compounds and derivatives thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1151523

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.