Amino and peptido modified enzymatic nucleic acid

Details Amino and peptido modified enzymatic nucleic acid Amino and peptido modified enzymatic nucleic acid

1994-12-16

1998-07-21

Degen, Nancy

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435325, 536 231, 536 245, C07H 2100, C12N 500, C12N 508

Patent

active

057834253

ABSTRACT:
An enzymatic nucleic acid molecule, comprising a moiety having the formula: ##STR1## wherein B is a nucleotide base or hydrogen; R is selected from the group consisting of aminoacyl group, and NHR.sub.4 group, wherein said R.sub.4 is independently selected from the group consisting of a peptidyl group containing between 2 and 5 amino acids inclusive, and CO--CR.sub.1 R.sub.2 R.sub.3, wherein R.sub.1, R.sub.2 and R.sub.3 independently is selected from the group consisting of hydrogen, an alkyl group containing between 2 and 10 carbon atoms inclusive, and an alkyl amine; and the zigzag lines are independently hydrogen or a bond.

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